Men 10376 TFA

Research use only, not for human use.

Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.

Men 10376 TFA is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.(In Vitro):Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM). Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM).(In Vivo):Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats.

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Neurokinin-2 receptor antagonist TFA

Others

Other Targets

Ki: 4.4 μM (NK-2 receptor, rat small intestine)

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1195.25

C59H69F3N12O12

>98% (HPLC)

H2O : 1.43 mg/mL (1.20 mM; Need ultrasonic)

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Sequence:Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2

(-20℃)

With Ice Pack

≥ 2 years